Breast cancer patients who respond well to preoperative treatment may be able to skip surgery: Study


Advertisement

Patients diagnosed Breast cancer at an early stage Those who have had a good response to targeted cancer treatment before surgery — also known as adjuvant therapy — may be able to skip surgery and receive radiation therapy, with a low chance of cancer recurrence.


Advertisement

This is according to a new study conducted by researchers at MD Anderson Cancer Center at the University of Texas, One of the world’s most respected centers dedicated exclusively to cancer care and research.

Lead researcher Henry Koerer, MD, PhD said: “This research adds to the growing evidence showing that new drugs can completely eliminate cancer in some cases, and very early results show that we can safely eliminate surgery in this select group of women. women with breast cancer.” Dr.. , in a press release.

Breast cancer and mammograms: 3 key questions women of all ages should ask before having their scans

He is a professor of breast oncology at the University of Texas MD Anderson Cancer Center, in Houston, Texas.

The results of the phase II trial are published in the journal Lancet Oncology.

Lead researcher Henry Koerer, MD, PhD said: “This research adds to the growing evidence showing that new drugs can completely eliminate cancer in some cases, and very early results show that we can safely eliminate surgery in this select group of women. women with breast cancer.” Dr..
(iStock)

The researchers considered the possibility breast cancer Frequent in patients considered to be in complete remission after receiving chemotherapy and radiotherapy without surgery.

According to the study, 31 of the 50 patients who were followed up responded fully to chemotherapy – and none had a breast tumor recurrence after an average follow-up of 26.4 months.

Patients received specific cancer-targeted treatments and chemotherapy prior to surgery.

These types of breast cancer usually recur [the] The first two years, so [the] The short follow-up showed promising results.”

Keurer told Fox News Digital that patients received specific cancer-targeted therapies and chemotherapy before surgery.

Katie Couric’s Breast Cancer: What Other Women Can Learn From Her Diagnosis

“Patients often have surgery first, but these targeted therapies increase survival. So give it first – they shrink tumors, allowing lumpectomy versus mastectomy,” he said in an interview.

The multicenter study included 50 women over 40 years of age with triple-negative or HER2-positive breast cancer and a residual breast lesion less than 2 cm after standard chemotherapy.

If cancer is not detected in the biopsy, breast surgery is not performed and patients are prescribed standard radiotherapy.

A single image-guided, vacuum-assisted core biopsy (VACB) was performed on patients.

Singer Kelly Lang on her 17-year battle against breast cancer: ‘I promised God I would be a bright light for others’

If cancer is not detected in the biopsy, breast surgery is not performed and patients are prescribed standard radiotherapy.

Among the participants, the VACB identified 31 patients who had a complete pathological response – which means that the pathologist does not detect cancer in the tissues in which the tumor is located.

"While these results are impressive and very promising, it is important for patients to know that this is the first start of a new type of treatment for certain patients," Principal investigator Henry Koerer, MD, PhD, said about the new study.

“While these results are fascinating and very promising, it is important for patients to know that this is the first start of a new type of treatment for certain patients,” lead researcher Henry Kuerer, MD, said about the new study.
(iStock)

“Patients who had a good response to treatment and evidence on imaging that the tumor was responding well — rather than surgery, we used imaging biopsy and skip surgery in these patients,” Koerer said.

He also explained that high response rates, combined with selective, image-guided VACB and strict histological processing (the study of tissues and cells), improved clinicians’ ability to identify patients who might not need surgery.

He said the biopsy protocol designed by the MD Anderson Clinic was found to be quite accurate in the researchers’ previous research.

Breast Cancer Awareness: Kylie McEnany, Jerry Willis and Jackie Dingelis Find out the real diagnoses from Fox News

“We designed, tested and implemented the technology in 2018 and found an accuracy of 98% in this biopsy protocol,” he said.

Koerer also cautioned that more research is needed before this process becomes a standard of care.

Dr. Keurer's team at the University of Texas MD Anderson Cancer Center notes that this is a small, nonrandomized study — and that larger randomized studies are needed before changes in standards of care can be considered.

Dr. Keurer’s team at the University of Texas MD Anderson Cancer Center notes that this is a small, nonrandomized study — and that larger randomized studies are needed before changes in standards of care can be considered.
(Reuters/Jim Borg)

“Currently, standard surgery for breast cancer is still necessary,” Koerer said.

“While these results are fascinating and very promising, it is important for patients to know that this is the first start of a new type of treatment for certain patients.”

He added: “A lot Longer follow-up and more studies It will be necessary before this approach is incorporated into routine breast cancer care.”

The researchers will continue to follow these patients to monitor their long-term outcomes, Keurer said.

His team notes that this is a small, nonrandomized study – and that larger randomized studies are needed before changes in standard of care can be considered.

“This is an interesting and thought-provoking trial.”

“This is an interesting and thought-provoking experiment,” Sarah B. Kate, director of the Breast Surgery Quality Program at Mount Sinai Health System in New York, told Fox News Digital.

“Nationally, there are very few clinical trials looking at avoiding surgery for breast cancer,” said Kate, who was not involved in the study.

Click here to subscribe to our lifestyle newsletter

“However, long-term follow-up of these trials is needed to be extrapolated to the general breast cancer patient and for us to know that it is safe to offer them.”

CLICK HERE FOR FOX NEWS APP

Kate, who is also director of the Breast and Special Surveillance Program at Mount Sinai Health System, added, “This trial also included a very small number of patients who were treated without surgery. Changes in the standard of care will include a much larger trial with more patients.”



Source link

Leave a Comment